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 Which study design is the most powerful for generating evidence?

According to Tracy, O’Grady, and Phillips (2023), when taking all study designs into consideration, the randomized controlled trial (RCT) remains the gold standard research design for generating evidence. RCT remains the gold standard because it is based on three critical elements which includes manipulation of an experimental intervention; comparison of the group receiving the experimental intervention versus the group receiving the placebo; and randomized assignment to the experimental or control groups. Randomized assignment to the aforementioned groups helps to prevent bias from being introduced into the study and increases validity (Tracy et al., 2023).


Tracy, M. F., O’Grady, E. T., & Phillips, S. J. (2023). Hamric & Hanson’s Advanced Practice Nursing: An Integrative Approach (7th ed.).

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